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Earlier this year, the Drug Enforcement Administration issued an opinion contending that delta-8-THC-O and delta-9-THC-O (as distinguished from delta-8-THC and delta-9-THC) are illegal controlled substances. THC-O is another cannabinoid that can be derived from hemp and marijuana, like Delta-8-THC and Delta-9-THC, though it does not occur naturally in the plants. The DEA’s position reflects that, going forward, the DEA will likely scrutinize and oppose any hemp product that contains substances that do not naturally occur in hemp plants, even if the manufacturing process involves minimal intervention. There is a grey area between “extraction” and “synthesisation,” however, and there will almost certainly be litigation seeking to clarify where the DEA draws the line.